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BELIDES ORG
BelidesTM ORG is a natural skin-lightening agent, derived from organic daisy flowers (Bellis perennis). It is suitable for any skincare concept providing even and luminous complexion and radiant skin.
BelidesTM ORG's action is based on a potent, multifaceted reduction in the activity of melanocytes. BelidesTM ORG influences different cellular pathways involved in melanogenesis, encompassing the reduction of cellular signaling, tyrosinase transcription, tyrosinase activity and melanosome transfer. These actions lead to even pigmentation and make age spots less visible.
The extract obtained from Bellis perennis flowers consists of bioactive molecules such as saponins (triterpene glycosides), polyphenols (phenolic acid), flavonoid glycosides, polysaccharides and inulin. The presence of these ingredients suggests that this active produces a variety of effects which are also used in phytomedicine, among them antifungal, antimicrobial, antioxidative, anticancerogenic and neuroprotective effects.
Surprisingly, BelidesTM ORG was found to produce a strong inhibitory effect on melanogenesis. The fraction of polyphenols contained in this product is known to inhibit tyrosinase. Results of a comparative study conducted with BelidesTM ORG and arbutin, used at equivalent polyphenol concentrations, showed that BelidesTM ORG was about twice as active as arbutin. It was concluded that the skin-lightening effect produced by BelidesTM ORG was based on further inhibitory mechanisms.
In addition, BelidesTM ORG has been found to significantly inhibit the peptide hormone endothelin. Endothelin is released by stimulated keratinocytes and induces melanin synthesis via specific melanocyte receptors. The depigmenting activity of BelidesTM ORG hence is based on cumulative effects produced by different mechanisms:
- Inhibition of tyrosinase activity
- Reduction of tyrosinase synthesis by controlling its transcription
- Reduction of the melanin-stimulating mediator endothelin