Access to the full information on Coptis Ingredients database

Search and find the cosmetic ingredients you need
for your Cosmetics & Personal Care formulations:

  • more than 15,000 products
  • 50 combinable search criteria
  • 27,000 technical documents



CIRCALYS® - Chrono detox - Feel good energizer

- Concept of chronobiology
- Brain-skin axis modulation
- Psychobiological approach

CIRCALYS® is a natural active ingredient titrated in andrographolide extracted from the leaves of Andrographis paniculata, a major detoxifying plant in Ayurveda.

CIRCALYS® modulates skin circadian clock, by restoring a "young" invigorating clock gene expression profile in old/tired keratinocytes and by acting on circadian modulators related to key cellular pathways. CIRCALYS® extends cell longevity, reduces cell damages, promoting skin revitalization. CIRCALYS® also acts as a "Brain-Skin" axis booster, enhancing oxytocin, endocannabinoid and endorphin signaling pathways to relax skin.

Clinically tested on night/shift workers during 28 days, CIRCALYS® was proved to significantly reduce facial visible signs of fatigue (eye bags, dark circles, under-eye wrinkles, dull tone) and the impacts of fatigue on mood: the feeling of well-being was boosted, the perceived stress and the negative affect were reduced ("yoga-like" effect). CIRCALYS® is a chrono-detox active ingredient providing a "feel good energizing" effect.

China compliant
COSMOS authorized

Learn more

Subscribe to Coptis Ingredients to access all of the details of this product
Free trial of Coptis Ingredients